Background: It is widely accepted that metabolic syndrome is associated with an increased risk of chronic kidney\ndisease (CKD). To investigate whether coexisting metabolic syndrome is a necessary condition for CKD in\noverweight and obese.\nMethods: A cohort study of 6852 Chinese individuals from August 2007 to December 2012. Examinations included\na questionnaire, physical measurements, and blood sampling. Hazard ratios for incident CKD were estimated\naccording to combinations of BMI category and absence or presence of metabolic syndrome.\nResults: For CKD, multivariable adjusted hazard ratios vs. normal weight individuals without metabolic syndrome\nwere 1.31 (95 % CI, 0.89ââ?¬â??1.92) in overweight and 2.39 (95 % CI, 1.27ââ?¬â??4.52) in obese without metabolic syndrome\nand 1.54 (95 % CI, 1.18ââ?¬â??3.95) in normal weight, 2.06 (95 % CI, 1.27ââ?¬â??3.36) in overweight, and 2.77 (95 % CI, 1.42ââ?¬â??4.31)\nin obese with metabolic syndrome. There were no interactions between BMI and absence or presence of metabolic\nsyndrome on risk of CKD when BMI was categorized (normal weight, overweight, obese) (P = 0.17). Among\nindividuals both with and without metabolic syndrome there were increasing cumulative incidences of CKD from\nnormal weight through overweight to obese individuals (log-rank trend P = 0.04 to P < 0.001). Although the\nmultivariable adjusted hazard ratio for CKD in individuals with vs. without metabolic syndrome was 1.82 (95 % CI,\n1.20ââ?¬â??2.78) within overweight and obese individuals (log-rank P = 0.005), only 26.1 % of the increased risk observed\nfor BMI is explained by metabolic syndrome.\nConclusions: These findings suggest overweight and obesity are risk factors for CKD regardless of the presence or\nabsence of metabolic syndrome.
Loading....